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Interpolated variable order motifs for identification of horizontally acquired DNA: revisiting the Salmonella pathogenicity islands.

Identifieur interne : 002D14 ( Main/Exploration ); précédent : 002D13; suivant : 002D15

Interpolated variable order motifs for identification of horizontally acquired DNA: revisiting the Salmonella pathogenicity islands.

Auteurs : Georgios S. Vernikos [Royaume-Uni] ; Julian Parkhill

Source :

RBID : pubmed:16837528

Descripteurs français

English descriptors

Abstract

There is a growing literature on the detection of Horizontal Gene Transfer (HGT) events by means of parametric, non-comparative methods. Such approaches rely only on sequence information and utilize different low and high order indices to capture compositional deviation from the genome backbone; the superiority of the latter over the former has been shown elsewhere. However even high order k-mers may be poor estimators of HGT, when insufficient information is available, e.g. in short sliding windows. Most of the current HGT prediction methods require pre-existing annotation, which may restrict their application on newly sequenced genomes.

DOI: 10.1093/bioinformatics/btl369
PubMed: 16837528


Affiliations:


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Le document en format XML

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